Signed, audited GPU secondary analysis.
$149 per WGS sample.
Compute layer only. Not a clinical laboratory.

FASTQ in — aligned BAM, called VCF, QC report, and a signed Ed25519 provenance manifest out. Compute + artifacts only. The lab stays the CLIA/CAP lab of record.

Book a 30-min discovery call See the numbers

Compute + artifacts

What every per-report deliverable contains

One signed, audited bundle per sample. Verifiable on the lab's hardware in five seconds.

Aligned BAM + called VCF
DeepVariant via NVIDIA Parabricks 4.7.0-1, pinned by container digest. GRCh38_no_alt_analysis_set, SHA-pinned reference.
Signed Ed25519 manifest
JCS-canonical, detached signature. Verify offline against our published public key with our open-source genomics-verify CLI.
QC report (PASS/WARN/FAIL)
Machine-parseable JSON with reason codes: alignment rate, mean coverage, Ti/Tv, Het/Hom, variant counts. Schema-validated.
Hash-chained audit log
Append-only, per-tenant. Every state transition + artifact emission timestamped and hash-linked. Inspector-ready evidence.

Defensible, not aspirational

Reproducible numbers, published methodology

HG002 30× WGS DeepVariant via Parabricks 4.7.0-1 against GIAB v5.0q, scored under the same hap.py methodology as the PrecisionFDA Truth Challenge V2.

In-scope SNP F1
0.9993
within ±0.0005 of pFDA V2 leaders
In-scope Indel F1
0.9959
within ±0.0005 of pFDA V2 leaders
Wall-clock (single GB10)
1h 52m
30× WGS, fq2bam + DV-germline
Exclusion BED FN capture
97.3%
118,748 of 121,994 v5.0q FNs

In-scope numbers are scoped to the complement of the published exclusion BED (uncompressed SHA-256 7dc4d16b…3932c1c; GIAB v3.6 alldifficultregions minus MHC ∪ chrX/Y non-PAR/XTR/ampliconic). The MHC / HLA region is in scope. Numbers are within ±0.0005 of the top short-read submissions in the PrecisionFDA Truth Challenge V2 — Illumina DRAGEN v4.x (anonymized submission W607K), Sentieon DNAscope (KXBR8), Google DeepVariant Open Source (BSODP) — re-scored under identical hap.py / vcfeval methodology and identical GIAB v3.6 stratifications (Olson 2022, DOI 10.5281/zenodo.6384789). Definitive numbers and methodology archive are in the customer bundle.

From FASTQ to verified VCF

How it works

Step 1

Ship FASTQ

Globus, GCS BYOB, signed URL, or SFTP. ~70 GB pair for a typical 30× WGS sample.

Step 2

Pipeline runs

Parabricks DeepVariant on GPU. ~2 hours on a single GB10; faster on burst capacity. Container digest pinned.

Step 3

Artifacts signed

BAM + VCF + QC report + JCS-canonical signed manifest + audit-log entries. Every SHA-256 bound by signature.

Step 4

Lab verifies offline

One command. No network. Cross-check against the fingerprint pinned in the executed pilot agreement.

$ genomics-verify manifest.json signature.json --public-key genomics-public.pem
OK — signature valid for this manifest.
  algorithm:       ed25519
  public key id:   <fingerprint pinned in the pilot agreement>
  manifest sha256: <hex>
  job_id: <uuid>
  sample_id: <your sample id>
  outputs: 3 file(s)

Per-report pricing

Pay per sample. No box capex.

Free pilot for the first 5–10 samples while the Lab validates concordance against its existing pipeline.

Free Pilot

$0/ sample

5–10 samples, free. The Lab keeps the side-by-side concordance report regardless of outcome.

  • Compute + all artifacts
  • Validation report + signed manifest
  • Non-binding LOI
Start the pilot

Standard

Most labs start here

$149/ WGS sample

All-inclusive per-report price. WES from $79.

  • ≤24h turnaround
  • BAM + VCF + QC + signed manifest + audit
  • BAA-ready (Google Cloud BAA in place)
  • Monthly invoice, Net 30
Convert from pilot

Priority

$249/ WGS sample

Same-day turnaround SLA with a dedicated reserved GPU.

  • Same-day turnaround SLA
  • Everything in Standard
  • Dedicated GB-class reservation
Talk to sales

Enterprise: volume discounts, custom SLAs, dedicated GCS project, white-label deployments. Available for labs at 200+ samples / month. Talk to sales →

Intended-use boundary

We are compute + artifact delivery. The Lab is the lab of record.

We deliver secondary analysis only: FASTQ → BAM, VCF, gVCF, QC report, signed provenance manifest, audit-log entries.

The customer laboratory is the CLIA/CAP lab of record and performs all clinical interpretation, variant classification, report sign-out, and patient communication. We do not diagnose, do not classify pathogenicity, do not sign out reports, and do not recommend treatment.

Quality numbers cited above are conditional on the platform staying inside its locked intended use and the published exclusion BED. Customer written acknowledgement of the exclusion BED is required before any GIAB v5.0q-scoped quality claim is published for that Lab.

Send us a sample. Free.

5 to 10 samples, $0. We return signed BAM/VCF/QC plus a side-by-side concordance report against your existing pipeline. The dossier walks through every artifact. No commitment.

Or email us directly at hello@datamade.ai.