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Title: Letter of Intent — Free Pilot (One-Page) Version: 0.1.0-draft Status: Template — populate placeholders, send within 24 h of discovery call Owner: Commercial Lead Last Reviewed: 2026-05-07 Next Review: 2026-08-07

Letter of Intent — {{COMPANY_NAME}} ⇄ {{CUSTOMER_LAB}}

Free Pilot — GCP-native GPU-accelerated secondary analysis

This is a non-binding Letter of Intent capturing the shape of a free validation pilot. The full Pilot Agreement (PILOT_AGREEMENT.md) follows once both parties sign below.

A more detailed multi-section variant lives at LOI_TEMPLATE.md; this one-pager is the artifact to send within 24 hours of a successful discovery call to capture momentum.

Parties

Provider Lab
Entity {{COMPANY_NAME}} {{CUSTOMER_LAB}}
Primary contact {{COMPANY_CONTACT_NAME}} ({{COMPANY_CONTACT_TITLE}}) {{CUSTOMER_CONTACT_NAME}} ({{CUSTOMER_CONTACT_TITLE}})
Email {{COMPANY_CONTACT_EMAIL}} {{CUSTOMER_CONTACT_EMAIL}}

Pilot scope

Per-sample deliverable

Every sample returns:

Data handling

Pilot success criteria

The pilot is PASS if all hold across the agreed sample set:

Criterion Target
In-scope SNP F1 against v4.2.1 (HG002 30×) ≥ {{SNP_F1_TARGET}} (default 0.995)
In-scope Indel F1 against v4.2.1 (HG002 30×) ≥ {{INDEL_F1_TARGET}} (default 0.99)
Manifest signature verification (every sample) 100% verify=True
Audit chain integrity (entire pilot run) validate_chain returns clean
Standard turnaround (≤24h target) Hit on 100% of pilot samples
Lab's parallel-comparison concordance against existing pipeline ≥ {{LAB_CONCORDANCE_TARGET}} on the in-scope complement

The Lab is the final arbiter of whether the pilot meets its internal QMS standard. We provide the evidence; the Lab signs off on its own timeline.

Path to paid volume pricing

Post-pilot, on Lab signoff:

No expiration on converting a successful pilot to Standard rates. First Standard invoice is monthly in arrears, Net 30.

Open items to close before pilot kickoff

Open item Owner Target
{{OPEN_ITEM_1}} (e.g. "BAA executed if PHI in scope") {{OWNER}} {{DATE}}
{{OPEN_ITEM_2}} (e.g. "Lab confirms preferred ingestion: Globus / GCS BYOB / SFTP") Lab {{DATE}}
{{OPEN_ITEM_3}} (e.g. "Lab supplies capture-kit BED if WES in scope") Lab {{DATE}}
Pilot Agreement executed Counsel both sides {{DATE}}

Non-binding statement

This LOI is non-binding other than as to confidentiality of discussions and any sample data shared during scoping. Either party may walk away before signing the formal Pilot Agreement without liability beyond reimbursable costs already incurred at the other's written request. The Pilot Agreement, once executed, supersedes this LOI in full.

Signatures

Provider — {{COMPANY_NAME}} Lab — {{CUSTOMER_LAB}}
_______ _______
{{COMPANY_SIGNATORY_NAME}}, {{COMPANY_SIGNATORY_TITLE}} {{CUSTOMER_SIGNATORY_NAME}}, {{CUSTOMER_SIGNATORY_TITLE}}
Date: ____ Date: ____

Diligence package (for the Lab's bioinformatics + QMS + counsel review): full clinical-readiness dossier at ../README.md. Highlights: INTENDED_USE.md, QUALITY_METRICS.md, PIPELINE_LOCK.md, V5_0Q_GAP_ANALYSIS.md, HIPAA_TECHNICAL_SAFEGUARDS.md, SIGNING_KEY_PUBLISHING.md, API_OPENAPI.json.

Appendix A — Signing-key fingerprint (pinned at execution). The Lab pins the production public-key SHA-256 fingerprint here at signature time and treats it as the trust anchor for every signed manifest delivered under this pilot. Rotation overlap, revocation, and historic keys are governed by SIGNING_KEY_PUBLISHING.md §5.

Key ID Fingerprint (SHA-256 of PEM) Status
{{KEY_ID}} {{KEY_FINGERPRINT}} Pinned for this pilot